About this treatment area
PT-141 (bremelanotide) is FDA-approved as Vyleesi for hypoactive sexual desire disorder in premenopausal women. It works through melanocortin receptors in the brain rather than blood flow, making it a different mechanism from PDE5 inhibitors. Clinics prescribe it off-label for men and postmenopausal women.
Relevant peptides
Regulatory status as of September 2026. Always confirm with your provider.
PT-141 (Bremelanotide)
FDA-approved as Vyleesi for one specific indication. Widely prescribed off-label.
Oxytocin
FDA-approved for labor induction. Compounded nasal spray used off-label for intimacy.
Kisspeptin
Studied for sexual arousal and testosterone stimulation. Investigational.
Melanotan II
Not approved anywhere. Serious safety concerns. Legitimate clinics do not prescribe.
Kisspeptin
Stimulates natural testosterone via GnRH. Investigational.
MK-677
Oral GH secretagogue. Not a peptide. Not approved. Banned in sport.